Effect of Sodium Salicylate on Magnesium Metabolism in the Rabbit.

Abstract

Summary Intravenous administration of sodium salicylate, 150 mg/kg twice within 2 hours to normal rabbits, resulted in a significant decrease in the tissue magnesium content of bone cortex, brain, appendix, heart, kidney, liver, and lung. The turnover of magnesium, as measured by Mg²⁸, was increased in the bone marrow, kidney, and liver. In animals given sodium salicylate in daily doses of 40 mg/kg for 6 days, tissue magnesium content was significantly decreased in bone cortex, brain, appendix, adrenal, heart, kidney, liver, lung, muscle, skin, stomach, and testis. The relative specific activity was increased in the brain, appendix, heart, kidney, lung, and stomach. In rabbits, sodium salicylate depletes the tissues of magnesium and increases the turnover of this element in the body.