Further Characterization of an Insulin Antagonist in the Serum of Patients in Diabetic Acidosis
Open Access
- 1 November 1957
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 36 (11), 1588-1593
- https://doi.org/10.1172/jci103557
Abstract
An insulin antagonist occurring in the sera of some patients in diabetic acidosis has been further characterized. It is inactivated by chymotrypsin but not by trypsin and migrates electrophoretically as an a1-globulin. The antagonist inhibits human as well as beef-pork insulin. It is suggested that the antagonist may be of etiologic significance in some cases of diabetes.This publication has 11 references indexed in Scilit:
- STUDIES ON INSULIN ANTAGONISM IN PLASMAEndocrinology, 1957
- Humoral insulin antagonism associated with diabetic acidosisAmerican Journal Of Medicine, 1956
- Studies on Humoral Insulin Antagonists in Diabetic AcidosisDiabetes, 1956
- EVIDENCE FOR THE INSULIN-DIRECTED SPECIFICITY OF RABBIT ANTI-INSULIN SERUM 1Journal of Clinical Investigation, 1956
- Studies on the biosynthesis of insulin I. The paper chromatographic isolation of 14C-labeled insulin from calf pancreas slicesBiochimica et Biophysica Acta, 1956
- PLASMA-INSULIN ACTIVITY IN DIABETES MELLITUS MEASURED BY THE RAT DIAPHRAGM TECHNIQUEThe Lancet, 1955
- Reduction by Glucagon of Glycogen Deposition Effect of Insulin in Rat Diaphragm.Experimental Biology and Medicine, 1955
- Über Serumeiweissveränderungen beim Diabetes mellitusKlinische Wochenschrift, 1955
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- Preparation of Crystalline InsulinIndustrial & Engineering Chemistry, 1940