Comparison of the binding of optically pure (?)- and (+)-[3H]nicotine to rat brain membranes
- 1 February 1985
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 10 (2), 259-267
- https://doi.org/10.1007/bf00964572
Abstract
A comparison of the binding of (−)- and (+)-[3H]nicotine to rat brain membranes revealed that only the (−)-enantiomer showed high affinity binding; while the (+)-enantiomer was at least 1/10 as effective as the (−)-enantiomer when in competition with (−)-[3H]nicotine as the ligand. Positive cooperativity, which is observed with (−)-[3H]nicotine as the presence of low concentrations of (+)-nicotine, may account for the seeming paradox.Keywords
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