Rapid Migration of111Indium-Labeled Granulocytes to Sites of Infection

Abstract

ISOTOPIC labels attached to various blood cells have been used for years to study the course and kinetics of blood components in vivo. The use of such labeling in granulocytes to evaluate transfusions or to localize infections has met with uncertain success.^{1 2 3 4 5 6 7} Recently, ¹¹¹In combined with the chelating agent 8-hydroxyquinoline (oxine) has been used in granulocyte-labeling research.^{8 9 10} The advantages of ¹¹¹In include tight cytoplasmic binding with minimal in vivo elution and preservation of cell viability and function after the granulocytes are exposed to the isotope.¹¹ In addition, the energy spectrum of this element consists of two peaks at 173 and . . .