The effect of X-radiation in vivo on protein and nucleoprotein metabolism in the rat

Abstract

The incorporation of labeled glycine, lysine and phosphate into various fractions of rat tissue was examined 2 hours after 1000 r X-radiation. The uptake of P32 and (2-C14) glycine by rat-thymus DNA was reduced by X-radiation. Incorporation of (2-C14) glycine and (C14) lysine into thymus nucleoproteins was also lowered; uptake into liver nucleoproteins was not affected. Incorporation into cytoplasmic proteins of thymus, liver and pancreas was unaffected or slightly increased. The difference in radiosensitivity between thymus and liver is discussed.