Treatment of Respiratory Acidosis with N-Allylnormorphine (Nalline)
- 28 May 1953
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 248 (22), 931-934
- https://doi.org/10.1056/nejm195305282482203
Abstract
IN 1943 Unna1 first reported the results of animal studies on the antagonistic properties of N-allyl-normorphine (Nalline) to morphine. In recent years, the therapeutic application of these properties has been under investigation in human subjects.2 3 4 Nalline is chemically related to morphine by the substitution of an allyl bromide group in the morphine radical.1 , 5 It counteracts the toxic effects of morphine in animals, especially the depression of respiration, and in some animals it apparently serves as a mild analgesic drug.1 In human beings it not only has no demonstrable analgesic activity in itself but also abolishes the analgesic effects of morphine . . .Keywords
This publication has 4 references indexed in Scilit:
- USE OF N-ALLYLNORMORPHINE IN TREATMENT OF METHADONE POISONING IN MANJAMA, 1952
- N-ALLYL-NORMORPHINE IN THE TREATMENT OF MORPHINE OR DEMEROL NARCOSISThe American Journal of the Medical Sciences, 1952
- Effects of N-allylnormorphine on CholinesterasesExperimental Biology and Medicine, 1951
- Protective Action of N-Allyl-Normorphine Against Respiratory Depression Produced by Some Compounds Related to Morphine.Experimental Biology and Medicine, 1950