THE HEMODYNAMIC EFFECT OF THE DIOXANE DERIVATIVE 933 F ON TRAINED UNANESTHETIZED NORMAL AND RENAL HYPERTENSIVE DOGS AND ITS EFFECT ON THE PRESSOR ACTION OF RENIN

Abstract

A method of studying the herao-dynamic action of drugs in trained unanesthetized dogs was described. This method was found to cause no discomfort nor any significant hemodynamic change when saline soln. in the quantities used to dissolve the drugs was injected intraven. The dioxane derivative 933 F in doses of 1 to 5 mg./kg. produced a reversal or inhibition of the adrenalin pressor action in the trained unanesthetized dog. Intraven. inj. of 933 F produced a quantitatively similar depressor action in the normal and hypertensive unanesthetized dog. The chemical mediator of exptl. renal hypertension was apparently not sympatho-mimetic in action. The pressor material, renin, obtained from kidney extracts, had a quantitatively similar action in normal and hypertensive dogs. This pressor effect was not inhibited, reversed or abolished by 933 F. Renin, apparently did not act as a sympatho-mimetic substance.