THE RECOVERY OF AN ADRENALIN-LIKE SUBSTANCE FROM THE KIDNEY

Abstract

Kidneys of dogs and pigs were perfused with normal saline at varying intervals after death. It was shown that renal perfusate contains 2 pressor substances: (1) A heat-labile, non-dialysable, alcohol-insoluble substance which is similar to Tigerstedt''s renin, and (2) a heat-stable, dialys-able, quick-acting pressor substance which is similar in action to adrenalin in solutions of 1:100,000 to 1:1,000,000. Its effect is enhanced by cocaine and abolished by ergotamine. It dilates the enucleated pupil of a frog''s eye. Greater concs. of this pressor substance are obtained several hrs. after death than are obtained immediately on removal of the kidney. The authors conclude that this pressor substance is either adrenalin or an adrenalin-like substance.