Comparison of Infection Rates and Severity of Illness for Influenza A Subtypes H1N1 and H3N2
- 1 January 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 151 (1), 73-80
- https://doi.org/10.1093/infdis/151.1.73
Abstract
In the Houston Family Study, overall rates of infection for the three major outbreaks of influenza A from 1977 to 1981 were higher for subtype H3N2 than for H1N1. Rates in school children were almost identical, but rates of infection with H1N1 were lower in adults and in preschool children, especially those younger than two years of age. However, rates for the two subtypes were similar in young children within families that experienced influenza A infections. In the total population overall illness rates among infected persons were identical, and diagnoses were similar. Among 145 identified primary infections (1977–1982), more H3N2 infections resulted in systemic (febrile) illness or lower-respiratory-tract disease, but a detailed comparison of illness features of 54 primary infections in children aged two to five years showed no significant differences. Epidemiological differences appear to be more important than pathogenic potential in determining the community impact of these two subtypes of type A influenza virus.Keywords
This publication has 17 references indexed in Scilit:
- DIFFERING VIRULENCE OF H1N1 AND H3N2 INFLUENZA STRAINSAmerican Journal of Epidemiology, 1980
- AN INFLUENZA OUTBREAK DUE TO A/USSR/77-LIKE (H1N1) VIRUS ABOARD A US NAVY SHIPAmerican Journal of Epidemiology, 1980
- Outbreak of Influenza A/USSR/77 at Marquette UniversityThe Journal of Infectious Diseases, 1980
- Microneutralization test for influenza A and B and parainfluenza 1 and 2 viruses that uses continuous cell lines and fresh serum enhancementJournal of Clinical Microbiology, 1980
- Reinfection with Influenza A (H3N2) Virus in Young Children and Their FamiliesThe Journal of Infectious Diseases, 1979
- LABORATORY-BASED SURVEILLANCE OF INFLUENZA VIRUS IN THE UNITED STATES DURING THE WINTER OF 1977–1978American Journal of Epidemiology, 1979
- Seroepidemiology of HlNl Influenza: Striking Differences in the Attack Rate Among Young PeopleActa Pathologica Microbiologica Scandinavica Section B Microbiology, 1979
- Interpandemic Influenza in the Houston Area, 1974–76New England Journal of Medicine, 1978
- RETURN OF EPIDEMIC A1 (H1N1) INFLUENZA VIRUSThe Lancet, 1978
- INFLUENZA IN CHINA IN 1977 - RECURRENCE OF INFLUENZA-VIRUS-A SUBTYPE H1N11978