MUSCLE STRENGTH IN MYOTONIA ATROPHICA (DYSTROPHIA MYOTONICA) IMPROVED BY TESTOSTERONE PROPIONATE

Abstract

Two [male] patients with myotonia atrophica and testic-ular atrophy, previously receiving only daily quinine, were given 25 mg. of testosterone propionate (Perandren) in-tramusc. every day for over 2 mos. The dynamometric response of the finger flexors was recorded graphically to note strength (single maximal contraction), total work, and maximal flexion rate before and during treatment. Within the 2 wks. after treatment strength rose to more than twice the original level and total work was increased by more than half the original amt. This status was maintained throughout the course of therapy and both patients showed general constitutional improvement. One [male] patient with progressive muscular dystrophy and normal gonads showed no improvement on similar treatment. 6 normal untreated controls showed no appreciable strength changes.