A serum factor capable of stimulating hyaluronic acid synthesis in cultured rat fibroblasts
- 1 May 1977
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 91 (2), 323-328
- https://doi.org/10.1002/jcp.1040910217
Abstract
Calf serum as well as rat and mouse sera has a factor that stimulates hyaluronic acid synthesis in cultured rat fibroblasts. Such a factor was partially purified from calf serum and characterized. It has a molecular weight of approximately 150,000. The activity of the factor is lost by treatment with pronase and by periodate oxidation. It is suggested, therefore, that the factor is a glycoprotein. Its susceptibility to α‐mannosidase and affinity for Con A‐Sepharose may suggest that the factor contains a mannose residue(s) which is essential for the activity to induce hyaluronic acid synthesis.This publication has 12 references indexed in Scilit:
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