In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomography
- 1 January 1985
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 17 (1), 70-79
- https://doi.org/10.1002/ana.410170116
Abstract
In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using[11C]dimethyloxazolidinedione ([11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our result, which are consistent with reported [14C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more “acidic” than that of normal gray or white matter.This publication has 34 references indexed in Scilit:
- In vivo measurement of regional brain tissue pH using positron emission tomographyAnnals of Neurology, 1984
- Cerebellar blood flow and metabolism in cerebral hemisphere infarctionAnnals of Neurology, 1983
- Tumour pH in human mammary carcinomaEuropean Journal of Cancer and Clinical Oncology, 1982
- Intracellular p H of Mitogen-Stimulated LymphocytesScience, 1982
- Microgravimetric analysis of human brain tissue Correlation with computerized tomography scanningJournal of Neurosurgery, 1981
- The sodium channel and intracellular H+ blockage in squid axonsNature, 1980
- Measurement of brain tissue carbon dioxide content in vivo by emission tomographyBrain Research, 1979
- Measurement of regional cerebral blood volume by emission tomographyAnnals of Neurology, 1978
- The Intracellular pH‘ in the Brain in Acute and Sustained HypercapniaActa Physiologica Scandinavica, 1971
- ELECTROLYTE EQUILIBRIA IN ERYTHROCYTES DURING DIABETIC ACIDOSIS 12JCI Insight, 1953