The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1
Open Access
- 29 March 2011
- journal article
- Published by Taylor & Francis in ASN Neuro
- Vol. 3 (2), AN20100033
- https://doi.org/10.1042/an20100033
Abstract
DMF (dimethyl fumarate) exerts anti-inflammatory and prometabolic effects in a variety of cell types, and a formulation (BG-12) is being evaluated for monothera...Keywords
This publication has 38 references indexed in Scilit:
- Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammationJournal of Neuroinflammation, 2010
- Dimethylfumarate inhibits NF-κB function at multiple levels to limit airway smooth muscle cell cytokine secretionAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2009
- Beneficial Effects of Dimethyl Fumarate on Experimental Autoimmune MyocarditisArchives of Medical Research, 2008
- Dimethylfumarate Induces Immunosuppression via Glutathione Depletion and Subsequent Induction of Heme Oxygenase 1Journal of Investigative Dermatology, 2007
- Dimethylfumarate inhibits nuclear binding of nuclear factor ?B but not of nuclear factor of activated T cells and CCAAT/enhancer binding protein ? in activated human T cellsBritish Journal of Dermatology, 2007
- Increased CD8+ central memory T cells in patients with multiple sclerosisMultiple Sclerosis Journal, 2007
- Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltrationClinical and Experimental Immunology, 2006
- Hypoxia/Reoxygenation Differentially Modulates NF-κB Activation and iNOS Expression in Astrocytes and MicrogliaAntioxidants and Redox Signaling, 2006
- Evidence of covalent interaction of fumaric acid esters with sulfhydryl groups in peptidesJournal of Mass Spectrometry, 2005
- Dimethylfumarate for psoriasis: more than a dietary curiosityTrends in Molecular Medicine, 2005