SUCCESSFUL PREGNANCY FOLLOWING HYPOPHYSECTOMY DURING THE TWELFTH WEEK OF GESTATION*

Abstract

Panhypopituitarism followed the surgical removal of a chromophobe adenoma from a woman in the twelfth week of pregnancy. The patient received hydrocortisone, desiccated thyroid and vasopressin, and the pregnancy proceeded to term in normal fashion. Minimal lactation occurred post partum. Hormonal excretion was similar to that observed in normal pregnancy. This case illustrates that, provided adequate replacement therapy is given, complete or nearly complete functional ablation of the pituitary during the latter part of the first trimester is compatible with normal human pregnancy.