Altered Calcium Uptake in Cultured Skin Fibroblasts from Patients with Alzheimer's Disease

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Abstract
To the Editor: Altered calcium homeostasis may be important in the pathophysiology of aging1 , 2 (and Peterson C, Gibson GE: unpublished data) and Alzheimer's disease.3 4 5 At the molecular and cellular levels, Alzheimer's disease is associated with numerous biochemical changes in non-neuronal tissues.6 7 8 9 10 11 12 13 14 Therefore, calcium transport was examined in cultured skin fibroblasts from six patients with Alzheimer's disease, six age-matched controls, and four young controls. Fibroblasts can be studied under controlled conditions without donor drug or nutritional influences, so that differences can be attributed to the cell's overall genetic composition.15 , 16 All six patients with Alzheimer's disease had classic symptoms of global cognitive . . .