Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes
- 14 January 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 151 (3707), 209-210
- https://doi.org/10.1126/science.151.3707.209
Abstract
Glucose, sorbitol, fructose, and inositol are present in peripheral nerve and spinal cord. Marked elevation of these substances occurs in these tissues in mildly diabetic animals. These alterations provide biochemical mechanisms which could be significant in the etiology of diabetic neuropathy.This publication has 7 references indexed in Scilit:
- Identification of fructose in mammalian nerveBiochemical and Biophysical Research Communications, 1964
- The effect of diabetes on the content of sorbitol, glucose, fructose and inositol in the human lensExperimental Eye Research, 1964
- INSULIN RESPONSE OF PERIPHERAL NERVEMedicine, 1964
- Osmotic changes in experimental galactose cataractsExperimental Eye Research, 1962
- Studies on the metabolism of semen. 6. Role of hormones. Effect of castration, hypophysectomy and diabetes. Relation between blood glucose and seminal fructoseBiochemical Journal, 1950