Pushing the signal hypothesis: what are the limits?
- 1 January 1985
- journal article
- research article
- Published by Wiley in Biology of the Cell
- Vol. 52 (1), 1-8
- https://doi.org/10.1111/j.1768-322x.1985.tb00319.x
Abstract
Recent advances in understanding the in vitro translocation of nascent animal polypeptides across the endoplasmic reticulum (ER) membrane have established a molecular basis for the initial reactions predicted by the signal hypothesis. The first 2 events involve a transient arrest or nascent chain elongation, followed by a docking maneuver with the ER membrane which releases this block. It is not clear that such signal sequence-mediated transfer occurs in the case of all proteins, or for that matter in all cell-free translation systems.This publication has 42 references indexed in Scilit:
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