Modifications of the portacaval shunt in the rat
- 1 November 1965
- journal article
- letter
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 20 (6), 1357-1358
- https://doi.org/10.1152/jappl.1965.20.6.1357
Abstract
Two refinements of the end-to-side portacaval anastomosis in the rat, the superior mesenteric-caval and the splenocaval, have been presented along with a continuous-suture method which makes possible a more rapid surgical procedure. Rats have been maintained with these shunts for 6 months after which autopsies have shown the shunts to be patent. The superior mesentericcaval anastomosis offers a unique system for examining the influence of dietary products on the liver. The diversion of insulin in the splenocaval anastomosis may provide a liver condition more nearly like that of the diabetic patient than those experimental systems previously used. Both shunts are being utilized in this laboratory for further study of liver systems. liver function; suture methods Submitted on January 27, 1965This publication has 3 references indexed in Scilit:
- Glutamine Synthetase Activity in Rat Liver After Portacaval ShuntEndocrinology, 1964
- Effect of Insulin on Glutamine Synthetase Activity in Rat LiverEndocrinology, 1964
- Alloxan Diabetes and Insulin Effects on Amino Acid Incorporating Activity of Rat Liver Microsomes.Experimental Biology and Medicine, 1961