Haplotype study. Linkage between HLA‐A, B, C and Bf alleles: results obtained by different statistical methods

Abstract

325 HLA‐A, B and Bf haplotypes obtained from family studies were investigated. In addition, 216 of these were tested for HLA‐Cw2, Cw4, Cw5. Four different statistical methods were employed to study 2, 3 or 4 loci gametic associations in order to compare the results obtained by these different methods. Our results were then compared with those of other authors who employed similar methods. Piazza's method, used to identify gametic associations, was not able to show any 3 loci associations in our material. The Delta Standard Method employed in conjunction with Factorial Correspondence Analysis was found suitable for the study of chromosal prevalence in a population.