Studies in detoxication. 50. The isolation of methyl and ethyl glucuronides from the urine of rabbits receiving methanol and ethanol

Abstract

Methyl and ethyl beta-D-glucuronides were isolated from the urines of rabbits dosed with methanol and ethanol, respectively, and characterized as the crystalline triacetyl methyl esters. The glucuronides are only very minor metabolites of these alcohols. The excretion of increased amts. of glucuronic acid after feeding single doses of ethanol is complete within 24 hr. of dosing, whereas after methanol the increased excretion continues for 2-3 days.