Repeated treatment with antidepressant drugs increases the behavioural response to apomorphine
- 1 September 1984
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 60 (3-4), 273-282
- https://doi.org/10.1007/bf01249099
Abstract
The effect of repeated treatment (twice a day for 14 days) with antidepressant drugs (AD): imipramine, amitriptyline, zimelidine, citalopram and mianserin on the behavioural response to apomorphine in rats (open field test) was investigated. AD studied, given alone in a single dose or repeatedly, do not change the rats behaviour. A repeated but not single-dose treatment with AD facilitates the behaviour stimulation induced by apomorphine. This facilitation is observed 2 hours after the last dose of imipramine, zimelidine, citalopram and mianserin but 72 hours after the last dose of amitriptyline. The results presented suggest that the AD given repeatedly are able to increase the responsiveness of the brain DA system, probably the mesolimbic one.This publication has 34 references indexed in Scilit:
- The effect of chronic treatment with antidepressant drugs on salbutamol-induced hypoactivity in ratsPsychopharmacology, 1983
- (+)-Oxaprotiline but not (-)-oxaprotiline given chronically potentiates the aggressive behaviour induced by clonidineJournal of Pharmacy and Pharmacology, 1983
- Pharmacokinetics of Amitriptyline N-Oxide in Rats after Single and Prolonged Oral AdministrationPharmacopsychiatry, 1983
- Do antidepressants induce dopamine autoreceptor subsensitivity?Nature, 1982
- A Possible Role of Serotonin Receptors in Antidepressant Drug ActionPharmacopsychiatry, 1982
- Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in miceJournal of Neural Transmission, 1982
- Chronic treatment with antidepressants: Potentiation of clonidine-induced aggression in mice via noradrenergic mechanismJournal of Neural Transmission, 1981
- Repeated tricyclics induce a progressive dopamine autoreceptor subsensitivity independent of daily drug treatmentNature, 1980
- Chronic treatment with antidepressants prevents the inhibitory effect of small doses of apomorphine on dopamine synthesis and motor activityLife Sciences, 1979
- Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depressionPsychopharmacology, 1977