Primaquine liposomes in the chemotherapy of experimental murine malaria
- 1 August 1980
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 74 (4), 383-391
- https://doi.org/10.1080/00034983.1980.11687359
Abstract
Due to a significant reduction of toxicity, 100% curative (causal prophylactic) doses of primaquine diphosphate entrapped in liposomes (60 and 70 mg/kg body weight) can be administered in a single intravenous injection to treat sporozoite-induced Plasmodium berghei infections of mice. Although drug activity is not enhanced as compared to free drug, a simplified experimental therapy scheme could be developed, which may facilitate comparative pharmacokinetic studies of various drug delivery systems.This publication has 16 references indexed in Scilit:
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