COMPARATIVE EFFECT OF ACTH, CORTISONE AND DCA ON RENAL FUNCTION, ELECTROLYTE EXCRETION AND WATER EXCHANGE IN NORMAL DOGS

Abstract

The inadequacies of our knowledge of the role of adrenocortical hormones in the regulation of electrolyte and water metabolism are becoming increasingly apparent (Gaunt, et al., 1949; Ingle, 1950; Sayers, 1950). Extensive and numerous observations on the action of DCA have been reported (Ragan, et al., 1940; Ferrebee, et al., 1941; Mulinos, et al., 1941; Zierler and Lilienthal, 1948; Gaudino and Levitt, 1949; Davis, et al., 1951; Luft and Sjögren, 1952; Sjogren, 1952), but data on the effect of 11,17-oxysteroid hormones in the dog are meager (Thorn, et al., 1941; Davis, et al., 1951; Roberts and Pitts, 1952). The latter studies were with cortisone and observations with ACTH are necessary before adequate evaluation of the relation of the ACTH-adrenocortical system to salt metabolism can be made. An important consideration which has been neglected in most studies with ACTH and cortisone in the dog