Autolysis and Secondary Growth of Mycobacterium tuberculosis in Submerged Culture
- 1 April 1967
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 93 (4), 1374-+
- https://doi.org/10.1128/jb.93.4.1374-1381.1967
Abstract
Mycobacterium tuberculosis has been found to exhibit autolysis and spontaneous secondary growth in modified Sauton Medium. The phenomenon is a function of high glycerol concentration of the medium and limitation of air in test tubes. It is not a function of depletion of nutrients and is probably not a manifestation of lysogeny or spheroplast formation. The cycle of growth, autolysis, and secondary growth is related to development of lethal conditions during a period of severe oxygen limitation followed by a metabolic change associated with slower depletion of glycerol.This publication has 13 references indexed in Scilit:
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