EXPRESSION OF A T-CELL ANTIGEN (LEU-1) BY B-CELL LYMPHOMAS
- 1 January 1983
- journal article
- research article
- Vol. 113 (2), 165-171
Abstract
The Leu-1 antigen has been defined by monoclonal antibodies (L17F12, T101, and OKT-1) as a pan-T-cell antigen present on all human peripheral blood T cells and thymocytes. Some cases of B-cell chronic lymphocytic leukemia have been found to react with these antibodies. Using a frozen section immunoperoxidase staining technique, 125 lymphomas [of humans] with B-cell differentiation were examined for the presence of Leu-1 antigen. Leu-1 antigen was detected in 4 of 11 cases of diffuse small lymphocytic lymphoma and 3 of 4 cases of diffuse intermediate lymphocytic lymphoma. Follicular lymphomas less often expressed this antigen: 2 of 29 cases of the small cleaved cell type, 0 of 13 cases of mixed small cleaved and large cell type, and 1 of 6 cases of large cell type. Diffuse lymphomas of presumed follicular center cell origin expressed this antigen infrequently as well, 1 of 3 cases of the small cleaved cell type, neither of 2 cases of mixed small cleaved and large cell type and 3 of 43 of large cell type (cleaved/noncleaved). Diffuse large cell, immunoblastic lymphoma of B-cell type expressed Leu-1 in 1 of 6 cases. None of the 3 cases of Burkitt''s lymphoma or of the 3 small noncleaved non-Burkitt''s lymphoma expressed detectable Leu-1. B-lymphoblastic lymphoma (1 case) and B-cell unclassified lymphoma (1 case) both failed to express detectable Leu-1. This pan-T-cell antigen is mainly found on those B-cell lymphomas composed predominantly of small lymphocytes. This finding may be of use in distinguishing extranodal neoplastic collections of small lymphocytes from lymphocytic hyperplasias.This publication has 25 references indexed in Scilit:
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