The effects of hypovolemic hypotension on high-energy phosphate metabolism of traumatized brain in rats
- 1 January 1988
- journal article
- research article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 68 (1), 129-136
- https://doi.org/10.3171/jns.1988.68.1.0129
Abstract
✓ To clarify the effect of hypovolemic hypotension on high-energy phosphate metabolism in head injury, sequential changes inin vivophosphorus-31 magnetic resonance (31P MR) spectra were compared in 35 rats after impact injury with and without hypotension. Fourteen rats were subjected to hypotension alone (mean arterial blood pressure (MABP) of either 40 or 30 mm Hg for 60 minutes), seven to fluid-percussion impact injury (4 to 5 atm) alone, and 14 to impact injury and hypotension (MABP of 40 to 30 mm Hg). Impact injury alone caused a transient decrease in the phosphocreatine (PCr) level and an increase in the inorganic phosphate (Pi) value. While hypotension alone produced only small changes on31P MR spectra, impact injury plus hypotension caused pronounced changes. Impact injury and an MABP of 40 mm Hg caused a 50% decrease in PCr concentration and an approximately twofold increase in Pi level, which were significantly greater than values in rats with impact injury alone. Impact injury and an MABP of 30 mm Hg also caused a significant decrease in adenosine triphosphate value, which was not observed in rats with impact injury alone or with an MABP of 30 mm Hg alone. Decreases in intracellular pH were greater in rats with impact injury and hypotension. After traumatic injury, the brain is extremely vulnerable to hypovolemic hypotension, as reflected in the loss of high-energy phosphates in brain.This publication has 42 references indexed in Scilit:
- Effect of Hypoxia on Traumatic Brain Injury in Rats: Part 2Neurosurgery, 1987
- An in vivo31P NMR study of cerebral hypoxic hypoxia in ratsMagnetic Resonance in Medicine, 1986
- Regional brain metabolite levels following mild experimental head injury in the catJournal of Neurosurgery, 1985
- Acute changes in regional cerebral metabolite values following experimental blunt head traumaJournal of Neurosurgery, 1985
- In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticusAnnals of Neurology, 1984
- Cerebral circulation after head injuryJournal of Neurosurgery, 1983
- A31P Nuclear Magnetic Resonancein vivoStudy of Cerebral Ischaemia in the GerbilJournal of Cerebral Blood Flow & Metabolism, 1982
- 31PHOSPHATE NUCLEAR MAGNETIC RESONANCE SPECTROMETRY DURING CEREBRAL HYPOXIAAnesthesiology, 1982
- THE INFLUENCE OF SHOCK ON MORTALITY AFTER HEAD TRAUMACritical Care Medicine, 1980
- Cerebral Metabolic Rate of Oxygen (CMRO2) in the Acute Phase of Brain InjuryActa Anaesthesiologica Scandinavica, 1978