Effects of Desipramine Treatment upon Central Adrenoceptor Function in Normal Subjects
- 1 August 1984
- journal article
- research article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 145 (2), 139-145
- https://doi.org/10.1192/bjp.145.2.139
Abstract
Six normal subjects were given clonidine infusions after 0, 1 and 3 wk of treatment with desipramine (2 mg/kg) and at 1 and 3 wk after withdrawal from desipramine. The sedative and hypotensive effects of clonidine were inhibited after 1 and 3 wk of desipramine treatment, and returned to normal after stopping treatment without any rebound increase. Such a time-course can be explained in terms of the acute effects of the drug, no adaptive changes at receptors need be invoked. By contrast, the growth hormone response to clonidine tended to be increased after 1 wk of desipramine, reduced after 3 wk of treatment, and further reduced after discontinuation. Such a time-course is consistent with an adaptive down regulation at .alpha.2 adrenoceptors in response to their acute stimulation, due to norepinephrine re-uptake blockade.This publication has 50 references indexed in Scilit:
- A Comparison of the Growth Hormone Responses to Clonidine and Apomorphine in the Same Patients with Endogenous DepressionThe British Journal of Psychiatry, 1984
- A Neuroendocrine Study of Stereotactic Sub-Caudate TractotomyThe British Journal of Psychiatry, 1984
- α2-Adrenergic stimulation enhances growth hormone secretion in the dog: A presynaptic mechanism?Life Sciences, 1983
- The effect of single and chronic administration of imipramine on clonidine-induced hypothermia in the ratLife Sciences, 1981
- Growth Hormone and other Responses to Clonidine in Patients with Endogenous DepressionThe British Journal of Psychiatry, 1981
- Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethylene-glycol sulphate content.Life Sciences, 1981
- Functional evidence for subsensitivity of noradrenergic α2 receptors after chronic desipramine treatmentLife Sciences, 1980
- A Neuroendocrine Study of the Mechanism of Action of ECTThe British Journal of Psychiatry, 1980
- Clonidine: Attenuation of sedative action by facilitated central noradrenergic neurotransmissionJournal of Neural Transmission, 1980
- A comparison of the cardiovascular effects of centrally administered clonidine and adrenaline in the anaesthetized ratJournal of Pharmacy and Pharmacology, 1979