2 MODELS FOR A MATERNAL FACTOR IN THE INHERITANCE OF HUNTINGTON DISEASE
- 1 January 1983
- journal article
- research article
- Vol. 35 (5), 845-860
Abstract
Huntington disease is a classic example of an autosomal dominant trait. Over the years a number of investigators reported anomalies regarding the age of onset of the disease that are inconsistent with this paradigm. Two models are proposed in which a maternal factor, cytoplasmic in 1 case, autosomal or X-linked in the other, acts to delay onset in a manner consistent with the previously reported anomalies. Relevant data from the Huntington''s Disease Research Roster are presented that reinforce and extend the previous observations.This publication has 18 references indexed in Scilit:
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