STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS
Open Access
- 1 October 1938
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 68 (4), 505-512
- https://doi.org/10.1084/jem.68.4.505
Abstract
With the view of making new types of chemicals accessible for investigations on drug hypersensitiveness, methods have been devised for sensitizing animals with diazomethane and mustard oil, two non-aromatic compounds. Guinea pigs have been sensitized to diazomethane, a substance of high reactivity and known to cause severe allergic effects in man. With the second substance, allylisothiocyanate, likewise capable of forming conjugates with substances in the animal body, sensitization effects have been obtained in man and in hogs. Sensitization in human beings was successful with one out of six individuals treated. The observations indicate species and individual differences as regards the ability to become sensitized to various chemical compounds.This publication has 3 references indexed in Scilit:
- STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDSThe Journal of Experimental Medicine, 1937
- Versuche über Sensibilisierung der Haut mit Ascaridenantigen, sowie über das Verhalten der vasculären Überempfindlichkeit bei epithelialer SensibilisierungArchives of Dermatological Research, 1934
- Phenyl isocyanate protein compounds and their immunological propertiesBiochemical Journal, 1933