GLUCOCORTICOID STIMULATION OF THE BIOSYNTHESIS OF GLUTAMIC-ALANINE TRANSAMINASE
- 1 November 1963
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 50 (5), 912-918
- https://doi.org/10.1073/pnas.50.5.912
Abstract
Measurements of C14-leucine incorporation into liver glutamic-alanine transaminase in normal and prednisolone-treated rats has proved a direct demonstration of a severalfold greater rate of biosynthesis of the enzyme in the hormone-treated animals. The elevated rate of synthesis precedes and leads to the increase in the steady-state tissue level of the enzyme consequent to hormone administration. The half-life of the enzyme has been determined and found to be 3.5 days in normal animals and 1.2 days in prednisolone-treated animals.Keywords
This publication has 25 references indexed in Scilit:
- AN EFFECT OF TESTOSTERONE ON AMINO ACID INCORPORATION BY PROSTATIC RIBONUCLEOPROTEIN PARTICLESProceedings of the National Academy of Sciences, 1962
- Direct Evidence for an Increase in Enzyme Level as the Basis for the Glucocorticoid-induced Increase in Glutamic-Alanine Transaminase Activity in Rat LiverJournal of Biological Chemistry, 1962
- INDUCTION OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE IN RAT LIVER .4. EVIDENCE FOR AN INCREASE IN RATE OF ENZYME SYNTHESIS1962
- The effect of hypophysectomy and growth-hormone treatment of the rat on the incorporation of amino acids into isolated liver ribosomesBiochemical Journal, 1961
- The Synthesis of Carbamyl Phosphate Synthetase in Thyroxin-treated TadpolesJournal of Biological Chemistry, 1961
- The Molecular Turnover of Muscle AldolaseJournal of Biological Chemistry, 1960
- STUDIES OF TISSUE PERMEABILITY .6. PENETRATION AND PHOSPHORYLATION OF 2-DEOXYGLUCOSE IN THE DIAPHRAGM OF DIABETIC RATS1960
- Specificity of the Adaptive Response of Tyrosine-α-Ketoglutarate Transaminase in the RatJournal of Biological Chemistry, 1958
- FORMATION OF A CYCLIC ADENINE RIBONUCLEOTIDE BY TISSUE PARTICLESJournal of Biological Chemistry, 1958
- Enzymatic and Metabolic Adaptations in AnimalsPhysiological Reviews, 1956