Scintigraphy of Normal Mouse Ovaries with Monoclonal Antibodies to ZP-2, the Major Zona Pellucida Protein
- 31 August 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4665), 938-941
- https://doi.org/10.1126/science.6474160
Abstract
The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.This publication has 24 references indexed in Scilit:
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