Antithymocyyte Serum Treatment of Hamstres Inoculated with a Measles Virus Isolated from a Patient with Subacute Sclerosing Panencephalitis
- 1 January 1973
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 2 (3), 303-321
- https://doi.org/10.3109/08820137309022802
Abstract
Antithymocyte erum (ATS) treatment of hamsters inoculated with a strain of measles virus (Lec) isolated from a child with subecute sclerosing panencepbalitis resulted in acute neurologic abnormalities in intracranially inoculated, weanling hamsters normally refractory to diseaee caused by the virus. me incubation period uas 8–12 days. Virus could be isolated from the brains of the sick animals. Neutralizing antibody was present in lower titers in the sera of the ATS-treated hameters than in the sera of untreated virus control hamsters. At the time Am-treated hameters were ill, antibody cytotoxic for Lec virus-infected cells was found mainly in the sera of virus control hamsters having neutralizing antibody. Newborn hamsters inoculated intraperitoneally with virus did not show neurologic symptom unless treated with ATS. In these treated animals the incubation period was 3–6 weeks. The brain, spleen and lung of sow of the sick hamsters contained virus. No detectable neutralizing antibody uas present at the time of onset of illness. In those animls which survived infection, the antibody titers increased and have remined high over a period of 8–12 months, while the antibody titers of the virus control animls in the same experiments have decreased or remained negative.Keywords
This publication has 21 references indexed in Scilit:
- The effect of altered immune reactivity on experimental measles encephalitis in ratsArchiv für die gesamte Virusforschung, 1972
- Immune Complexes and Visceral Deposits of Measles Antigens in Subacute Sclerosing PanencephalitisBMJ, 1972
- Neurotropism of Measles Virus Variants in HamstersThe Journal of Infectious Diseases, 1971
- Subacute Sclerosing Panencephalitis: Isolation of Suppressed Measles Virus from Lymph Node BiopsiesScience, 1971
- Neurotropic Properties of Measles Virus in Hamsters and MiceThe Journal of Infectious Diseases, 1971
- MECHANISMS OF RECOVERY FROM A GENERALIZED VIRAL INFECTION: MOUSEPOXThe Journal of Experimental Medicine, 1970
- Subacute Sclerosing Panencephalitis: Isolation of Measles Virus from a Brain BiopsyNature, 1969
- CELLULAR AND HUMORAL RESPONSES TO MEASLES IN SUBACUTE SCLEROSING PANENCEPHALITISThe Lancet, 1969
- ADDITIONAL EVIDENCE OF THE RELATION BETWEEN SUBACUTE INCLUSION-BODY ENCEPHALITIS AND MEASLES VIRUSThe Lancet, 1967
- MEASLES-VIRUS ANTIBODY AND ANTIGEN IN SUBACUTE SCLEROSING PANENCEPHALITISThe Lancet, 1967