INFLUENCE OF SUXAMETHONIUM ON THE POTENCY OF ORG NC 45 IN ANAESTHETIZED PATIENTS

Abstract

The non-depolarizing neuromuscular block produced by Org NC45 was potentiated by the previous administration of suxamethonium 1 mg kg⁻¹, shown by twitch depression of 91.3±2.4% when the same dose of Org NC 45 was administered after recovery from suxamethonium compared with the control value of 71.9±6.5%. The recovery index was also prolonged from 8.1±0.3 to 10.4±1.0min after suxamethonium. The dose-response curves for Org NC 45 showed a 1.66 potentiation factor for ED₅₀ and 1.73 for ED_9.5, caused by the previous administration of suxamethonium. This interaction is likely to occur in the plasma.