The new combination of risk factors determining a high risk of gestational diabetes mellitus
- 1 December 2015
- journal article
- research article
- Vol. 40 (4), 239-247
Abstract
Aim. The aim of this study was to identify early markers of gestational diabetes mellitus (GDM) and to reveal the most significant of them. Methods. A total of 548 pregnant women were screened for GDM between weeks 24 and 28 of gestation, as defined by International Association of Diabetes In Pregnancy Study Groups (IADPSG) criteria, in a retrospective case-control study. First trimester maternal fasting glucose, anthropometric parameters and blood pressure were obtained from medical records. Classification Tree Method was used to identify combination of early pregnancy risk factors that predict the highest risk of the development of GDM in later pregnancy. Results. The combination of Body Mass Index (BMI) >38.6 kg/m(2) with, abdominal circumference >91.5 cm and fasting glucose >4.5 mmol/L was associated with a 13-fold increased risk of GDM as compared to women who do not have this combination of symptoms (OR 13.2 95% CI: 2.7-63.3, P4.5 mmol/L, abdominal circumference >91.5 cm with the presence of polycystic ovary syndrome (PCOS) was associated with a 6-fold increased risk of GDM as compared with women who do not have this combination of symptoms (OR=7.6, 95% CI: 1.9-30.02, P=0.003). Conclusion. A higher BMI, abdominal circumference, fasting glycemia in the first trimester of pregnancy and the presence of PCOS predict increased GDM risk. Taking these combinations into consideration may facilitate identification of women at particular risk for GDM.Keywords
This publication has 15 references indexed in Scilit:
- Risk Factors for Gestational Diabetes: from an Epidemiological StandpointPublished by Springer Nature ,2010
- First-Trimester Fasting Hyperglycemia and Adverse Pregnancy OutcomesDiabetes Care, 2009
- High Blood Pressure Before and During Early Pregnancy Is Associated With an Increased Risk of Gestational Diabetes MellitusDiabetes Care, 2008
- Longitudinal changes in the continuous glucose profile measured by the CGMS® in healthy pregnant women and determination of cut-off valuesEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2008
- Maternal Obesity and Risk of Gestational Diabetes MellitusDiabetes Care, 2007
- Gestational Diabetes, Pregnancy Hypertension, and Late Vascular DiseaseDiabetes Care, 2007
- Summary and Recommendations of the Fifth International Workshop-Conference on Gestational Diabetes MellitusDiabetes Care, 2007
- Weight Characteristics and Height in Relation to Risk of Gestational Diabetes MellitusAmerican Journal of Epidemiology, 2006
- Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetesDiabetic Medicine, 2004
- Fasting plasma glucose test at the first prenatal visit as a screen for gestational diabetesPublished by Wolters Kluwer Health ,2003