Template-directed synthesis of oligoadenylates catalyzed by Pb2+ ions
- 1 September 1979
- journal article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 13 (3), 203-214
- https://doi.org/10.1007/bf01739480
Abstract
The Pb2+ ion is an effective catalyst for the template-directed condensation of ImpA on poly(U). This reaction generates up to 35% of oligomers 5 or more units long. Furthermore, the product is predominantly 3′–5′-linked (75%) unlike that from the uncatalyzed reaction which is more than 90% 2′–5′-linked. The significance of metal-ion catalysis for prebiotic polynucleotide formation is discussed.Keywords
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