DIFFUSIONAL RELEASE OF WATER-SOLUBLE BIOACTIVE AGENTS FROM ETHYLENE-VINYL ACETATE COPOLYMERS
- 1 September 1983
- journal article
- research article
- Published by Taylor & Francis in Chemical Engineering Communications
- Vol. 22 (5-6), 303-315
- https://doi.org/10.1080/00986448308940064
Abstract
A model is presented for the diffusional release of theophylline and albumin from ethylene-vinyl acetate based polymeric systems with dynamically changing porosity. The model may be used to predict values of tortuosity of certain types of controlled drug delivery polymeric systems if drug dissolution limitations are negligible. The values of the tortuosity factor calculated indicate that small constrictions between large pores play an important role in the solute release behavior from these samples.Keywords
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