The Migration of Cells to the Thymus
- 1 January 1966
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 35 (4), 221-231
- https://doi.org/10.1159/000209127
Abstract
The specific activity of thymic DNA was determined in mice given a single intraperitoneal dose of tritiated thymidine following whole-body irradiation, thymic irradiation and thymic chilling. In normal mice the specific activity of the DNA remained unchanged for 24 hr. following infection. After 500 R whole-body irradiation the DNA synthesizing capacity of the thymus fell more steeply than after irradiation of the thymus alone. The specific activity of the DNA labelled while the thymus was chilled by means of a ''cold finger'' was reduced to 23.6% of the normal but rose progressively onrewarming. These results were explained on the basis of an influx into the thymus of cells originating elsewhere in the body.Keywords
This publication has 11 references indexed in Scilit:
- THE REGENERATION OF F1 HOST CELL SPLEEN AND THYMUS AT ECTOPIC SITES IN F1 ANIMALS INDUCED BY IMPLANTATION OF PARENTAL SPLEEN AND THYMUSThe Journal of Experimental Medicine, 1964
- AUTORADIOGRAPHIC STUDIES OF THE IMMUNE RESPONSEImmunology & Cell Biology, 1963
- ROLE OF THE THYMUS IN TRANSPLANTATION IMMUNITY*Annals of the New York Academy of Sciences, 1962
- Determination of Lymphocyte Turnover by Continuous Infusion of H3 ThymidineBlood, 1962
- Studies on the Fate of Lymphocytes. I. Labeling Small Thymic Lymphocytes with Tritiated ThymidineBlood, 1961
- TURNOVER OF THYMIDINE IN DNA OF MARROW AND INTESTINAL MUCOSA IN MICE, AND ITS RESPONSE TO ADMINISTRATION OF 5-FLUOROURACIL1961
- PROLIFERATION OF INJECTED LYMPH NODE AND THYMUS CELLS IN LETHALLY IRRADIATED MICEPlastic and Reconstructive Surgery, 1960
- The Differential Action of Irradiated and Chemically Treated Marrow on Survival and on Thymic Regeneration in Irradiated MiceRadiation Research, 1959
- CELLULAR PROLIFERATION IN THE MOUSE AS REVEALED BY AUTORADIOGRAPHY WITH TRITIATED THYMIDINEProceedings of the National Academy of Sciences, 1958
- The Role of the Spleen in Radiation Injury.Experimental Biology and Medicine, 1949