A QUANTITATIVE STUDY OF ADRENAL INFLUENCES UPON THE CELLULAR ELEMENTS OF BONE MARROW1

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Abstract
Employing a rapid, reproducible means for estimating total cellular numbers in the bone marrow, it is found that adrenalectomy in the salt-maintained rat results in decreased concentrations of erythroid and increased concentrations of eosinophilic cells. Cortisol and corticosterone, alone or in combination with desoxycorticosterone, stimulate erythropoi-esis in the adrenalectomized rat. Cortisol and corticosterone exert both eosinopenic and lymphopenic actions upon bone marrow. Erythropoietic action of adrenal steroids may be a consequence of improved circulation which involves delivery of essential nutrients to the blood forming organs or it may be the result of an anoxic state due to initial water retention.