Immune Response to Acute Diarrhea Seen as Circulating Antibody-Secreting Cells
- 1 November 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 158 (5), 1011-1016
- https://doi.org/10.1093/infdis/158.5.1011
Abstract
We studied the immune response to acute diarrhea by examining antibody-secreting cells among peripheral blood lymphocytes, which are believed to be derived from the intestinal mucosa and to be on their way back there. In 23 of 24 patients, a dramatic increase in the total number of cells actively secreting immunoglobulins was detected one week after onset of diarrhea, and most of the cells were secreting IgA. Cells secreting antibody specific to the pathogen (Campylobacter jejuni or Salmonella spp.) also appeared at this time but accounted for only a part of the total response. The data suggest that diarrhea induces a vigorous, apparently polyclonal response, including antibodies to normal intestinal flora. The response to the infective agent was outstanding and suggests that this method can be used to identify the causative agent of an infection.Keywords
This publication has 7 references indexed in Scilit:
- IDENTIFICATION OF AN INTESTINAL IMMUNE RESPONSE USING PERIPHERAL BLOOD LYMPHOCYTESThe Lancet, 1988
- IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans.Proceedings of the National Academy of Sciences, 1987
- Specific Immunoglobulin-Secreting Human Blood Cells After Peroral Vaccination Against Salmonella typhiThe Journal of Infectious Diseases, 1986
- Synthesis of Human ImmunoclobulinsIn Vitro: Comparison of two Assays of Secreted ImmunoglobulinJournal of Immunoassay, 1985
- CHOLERA ANTIBODY-PRODUCTION INVITRO BY PERIPHERAL-BLOOD LYMPHOCYTES FOLLOWING ORAL IMMUNIZATION OF HUMANS AND MICE1985
- A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cellsJournal of Immunological Methods, 1983
- A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cellsJournal of Immunological Methods, 1983