EFFECT OF ADRENOCORTICAL STEROIDS ON ANDROGEN EXCRETION BY ADRENALECTOMIZED ORCHIDECTOMIZED MEN*
- 1 May 1954
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 14 (5), 495-508
- https://doi.org/10.1210/jcem-14-5-495
Abstract
The urinary excretion of androgens by 2 elderly orchidecto-mized patients with prostatic cancer was detd. by bioassay (chick comb method) before and after adrenalectomy and during oral admn. of glucocorticoids. The already low level was further reduced following adrenalectomy during periods of no therapy except for small doses of ethinyl estradiol and desoxycorti-costerone acetate. Maintenance doses of cortisone (25 to 50 mg. daily) were administered without significant increase in androgen excretion but not to the level prior to adrenalectomy, and even 300 mg. daily resulted in only slightly higher values. At 300 mg. daily, corticosterone was less and hydro cortisone was considerably more effective than cortisone in increasing urinary androgens.Keywords
This publication has 13 references indexed in Scilit:
- Isolation of an Androgenic Compound from the Adrenal Venous Blood of Cows.Experimental Biology and Medicine, 1951
- THE EFFECT OF ADRENAL STIMULATION WITH ADRENOCORTICOTROPHIC HORMONE ON THE EXCRETION OF DEHYPROISOANDROSTERONE IN MAN1,2,3,4,5,6Endocrinology, 1951
- A COMPARISON OF ANDROGENS DETERMINED BIOLOGICALLY AND 17-KETOSTEROIDS DETERMINED CHEMICALLY IN URINE (NORMAL AND ABNORMAL)*Journal of Clinical Endocrinology & Metabolism, 1950
- THE 17-KETOSTEROIDS: THEIR ORIGIN, DETERMINATION AND SIGNIFICANCEPhysiological Reviews, 1950
- OBSERVATIONS ON THE PHYSIOLOGIC EFFECTS OF CORTISONE AND ACTH IN MANArchives of Internal Medicine, 1950
- URINARY STEROIDS ISOLATED AFTER ADMINISTRATION OF DEHYDROISOANDROSTERONE TO HUMAN SUBJECTSJournal of Biological Chemistry, 1947
- BILATERAL ADRENALECTOMY IN PROSTATIC CANCERAnnals of Surgery, 1945
- THE ADRENAL-GONAD RELATIONSHIPPhysiological Reviews, 1945
- Effects of Desoxycorticosterone Acetate on 17-Ketosteroid and Pregnanediol Excretions1Journal of Clinical Endocrinology & Metabolism, 1942
- Über Cortin, das Hormon der Nebennieren‐rinde. I. MitteilungHelvetica Chimica Acta, 1936