Effects of Hypotension on Rhesus Monkeys
- 1 June 1975
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 32 (6), 374-380
- https://doi.org/10.1001/archneur.1975.00490480040004
Abstract
Twenty-one late-juvenile rhesus monkeys were rendered profoundly hypotensive for 0-, 15-, or 30-minute periods by means of infusion of trimethaphan camsylate. Blood pressure was then restored to prehypotensive levels with phenylephrine infusions. Respiratory gas tensions and pH of arterial blood were maintained within their normal limits throughout experimental and recovery periods. Animals either recovered and showed no sequelae or diet 12 to 48 hours later of cardiorespiratory difficulties, often accompanied by brain swelling. Brain injury and death occurred in 64% of cases when arterial blood pressure was maintained at 25 mm Hg for up to 30 minutes. Multifocal myoclonus, depressed electroencephalographic activity, rises in cisternal cerebrospinal (CSF) pressure, respiratory depression, and characteristic changes in serum and cisternal CSF glucose followed episodes of controlled hypotension. Hypoxia and acidosis occurring during insult or recovery periods rather than hypotension itself probably account for neuropathological sequelae described by others.Keywords
This publication has 7 references indexed in Scilit:
- Two Classes of Dysergic Brain Abnormality and Their Conditions of OccurrenceArchives of Neurology, 1973
- Brain damage in the rhesus monkey resulting from profound arterial hypotension. II. Changes in the spontaneous and evoked electrical activity of the neocortexBrain Research, 1969
- Hypotension and Cerebral IschemiaInternational Anesthesiology Clinics, 1969
- Experimental Brain Damage in Dogs Due To Systemic, Induced Hypotension and Head-Up Tilt for Short PeriodsAngiology, 1966
- THE EFFECTS OF PROFOUND SYSTEMIC HYPOTENSION UPON THE BRAIN OF M. RHESUS: PHYSIOLOGICAL AND PATHOLOGICAL OBSERVATIONSBrain, 1966
- Carrier transport of glucose between blood and cerebrospinal fluidAmerican Journal of Physiology-Legacy Content, 1964
- EFFECTS OF DRUG-INDUCED HYPOTENSION ON THE ELECTRO-ENCEPHALOGRAM OF THE DOGAnesthesiology, 1954