THE KIDNEY AS A SOURCE OF GLUCOSE IN THE EVISCERATED RAT

Abstract

In the presence of the kidneys the conc. of sugar in the blood of the abdominally eviscerated rat at first fell but then remained at a nearly constant value for a period of many hrs. Loss of blood caused the prompt development of hypoglycemia in the non-nephrectomized, eviscerated rat. The conc. of sugar in the blood of the nephrectomized, eviscerated rat fell precipitously until the animal died. Adrenalectomy or the adm. of adrenal cortical hormones was without major, acute effect in the non-nephrectomized, eviscerated rat. During the period in which the eviscerated rat was able to maintain the conc. of sugar in its blood at a nearly constant value, fermentable reducing susbtance was added to the blood as it flowed through the kidneys.