Brain 5β-Reductase: a Correlate of Behavioral Sensitivity to Androgen
- 10 July 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4504), 244-246
- https://doi.org/10.1126/science.7244635
Abstract
Testosterone is converted in the dove (Streptopelia risoria) brain to 5 beta-reduced metabolites that do not affect behavior. In long-term castrated birds, which are relatively insensitive to the behavioral effects of testosterone, the activity of preoptic 5 beta-reductase is increased. The increase, which is specific to the preoptic area, is reversed by estrogen. Inactivation of testosterone by 5 beta-reduction may be involved in the control of brain sensitivity to androgen.This publication has 15 references indexed in Scilit:
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