Study of the evolution of acute phase reactants and of thromboxane and prostacyclin during calcium pyrophosphate-induced pleurisy in the rat
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 14 (1), 82-87
- https://doi.org/10.1007/bf01966838
Abstract
By using a clearly defined model of acute inflammation in rats, CaPP-induced pleurisy, we compared the evolution of four APR levels (Hp, HpX, α2M, SAP) at a local and peripheral site. At the same time we studied thromboxane and prostacyclin concentrations in pleural exudate. The levels of APR have shown a progressive increase up to 24 h. For α2M, Hp, HpX the increase in serum concentration was more rapid than in exudate, whereas the evolution of SAP level was parallel in the intra and extra-vascular compartments. On the other hand the levels of albumin and transferrin which are not APR remained constant in serum and also in exudate from 6 h to 24 h. Thromboxane and prostacyclin levels reached a peak during the first two hours of the inflammatory reaction followed by a rapid decrease. These prostanoids may be considered as early and transient mediators of acute inflammation, whereas the acute phase proteins studied have a more prolonged role in the inflammatory reaction.This publication has 23 references indexed in Scilit:
- Prostacyclin and thromboxanes in carrageenan-induced pleurisy in the ratInflammation Research, 1984
- A new pentraxin (serum amyloid P-component) in the rat: Evidence for two quaternary structures and effect of ligands on self-associationBiochimica et Biophysica Acta (BBA) - Protein Structure, 1981
- The role of macrophages in the acute-phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogenCellular Immunology, 1981
- Identification of the sites of albumin catabolism in the ratArchives of Biochemistry and Biophysics, 1981
- The effect of turpentine-induced inflammation on rat liver glycosyltransferases and golgi complex ultrastructureBiochimica et Biophysica Acta (BBA) - General Subjects, 1980
- Relationships between inhibition of rat polymorphonuclear chemotaxis and various inflammatory reactionsInflammation Research, 1979
- Determination immunochimique de l'hemoglobine humaine dans les liquides biologiquesClinica Chimica Acta; International Journal of Clinical Chemistry, 1977
- Nouvelle méthode de préparation de l'hémopexine de ratBiochimie, 1977
- Pyrophosphate-induced inflammation: An in vivo study of the interrelationship of intracellular cyclic AMP and cyclic GMPInflammation Research, 1976
- Calcium pyrophosphate-induced pleurisy in rats: A new model of acute inflammationInflammation Research, 1975