Tau phosphorylation by GSK-3β promotes tangle-like filament morphology
Open Access
- 28 June 2007
- journal article
- Published by Springer Nature in Molecular Neurodegeneration
- Vol. 2 (1), 12
- https://doi.org/10.1186/1750-1326-2-12
Abstract
Neurofibrillary tangles (NFTs) are intraneuronal aggregates associated with several neurodegenerative diseases including Alzheimer's disease. These abnormal accumulations are primarily comprised of fibrils of the microtubule-associated protein tau. During the progression of NFT formation, disperse and non-interacting tau fibrils become stable aggregates of tightly packed and intertwined filaments. Although the molecular mechanisms responsible for the conversion of disperse tau filaments into tangles of filaments are not known, it is believed that some of the associated changes in tau observed in Alzheimer's disease, such as phosphorylation, truncation, ubiquitination, glycosylation or nitration, may play a role.Keywords
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