"ALKALINE" PHOSPHATASE ACTIVITY OF THE PROXIMAL CONVOLUTED TUBULES AND THE MECHANISM OF PHLORIZIN GLYCURESIS

Abstract
The "alkaline" phosphatase activity of the renal tubules in acutely and chronically phlorizinized rats and dogs was detd. by the Gomori-Takamatsu histochemical technique and by chemical analysis of tissue extracts. No significant inhibition was found in animals showing maximal glycuresis. Phlorizin glycuresis is evidently not due to inhibition of "alkaline" phosphatase activity of the proximal convoluted tubules.