The Delayed Response of Chronic Lymphocytic Leukemia Lymphocytes to Phytohemagglutinin in Vitro
- 1 March 1968
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 127 (3), 668-671
- https://doi.org/10.3181/00379727-127-32769
Abstract
The kinetics of RNA, DNA, and protein synthesis were analyzed in normal and CLL lymphocytes stimulated by PHA in vitro. Normal cultures exhibited maximal increases in lymphocyte nucleic acid and protein synthesis 2 to 3 days after exposure to PHA. Under identical conditions the maximal response on the part of the lymphocytes in CLL cultures occurred between 5 to 7 days. Many CCL lymphocytes are capable of responding to PHA but the response is distinctly delayed.This publication has 9 references indexed in Scilit:
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