The efficacy of certain trypanocidal compounds against Trypanosoma gambiense infection in man

Abstract

In field trials carried out in n. Nigeria, melarsen proved to be the best drug tried. Melarsen oxide and Mel B were unsuitable for large-scale use because of their side effects. Pentamidine and tryparsamide were both valuable in the treatment of early cases; used together they are more useful than are antrypol-tryparsamide mixtures, and should replace the latter in general field use. Most of the patients were followed for a period of 2 years to determine the efficacy of the treatments.