Genetics and molecular biology of siderophore-mediated iron transport in bacteria.
- 1 December 1989
- journal article
- review article
- Vol. 53 (4), 517-30
Abstract
The possession of specialized iron transport systems may be crucial for bacteria to override the iron limitation imposed by the host or the environment. One of the most commonly found strategies evolved by microorganisms is the production of siderophores, low-molecular-weight iron chelators that have very high constants of association for their complexes with iron. Thus, siderophores act as extracellular solubilizing agents for iron from minerals or organic compounds, such as transferrin and lactoferrin in the host vertebrate, under conditions of iron limitation. Transport of iron into the cell cytosol is mediated by specific membrane receptor and transport systems which recognize the iron-siderophore complexes. In this review I have analyzed in detail three siderophore-mediated iron uptake systems: the plasmid-encoded anguibactin system of Vibrio anguillarum, the aerobactin-mediated iron assimilation system present in the pColV-K30 plasmid and in the chromosomes of many enteric bacteria, and the chromosomally encoded enterobactin iron uptake system, found in Escherichia coli, Shigella spp., Salmonella spp., and other members of the family Enterobacteriaceae. The siderophore systems encoded by Pseudomonas aeruginosa, namely, pyochelin and pyoverdin, as well as the siderophore amonabactin, specified by Aeromonas hydrophila, are also discussed. The potential role of siderophore-mediated systems as virulence determinants in the specific host-bacteria interaction leading to disease is also analyzed with respect to the influence of these systems in the expression of other factors, such as toxins, in the bacterial virulence repertoire.This publication has 95 references indexed in Scilit:
- How eukaryotic transcriptional activators workNature, 1988
- Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and TranslationScience, 1988
- Fur (ferric uptake regulation) protein and CAP (catabolite‐activator protein) modulate transcription of fur gene in Escherichia coliEuropean Journal of Biochemistry, 1988
- Biochemical Analysis of Spontaneous fepA Mutants of Escherichia coliMicrobiology, 1988
- Flanking and Internal Regions of Chromosomal Genes Mediating Aerobactin Iron Uptake Systems in Enteroinvasive Escherichia coli and Shigella flexneriMicrobiology, 1987
- Evidence for the Role of a Siderophore in Promoting Vibrio anguillarum InfectionsMicrobiology, 1986
- Hydroxamate siderophore mediated iron uptake in E.coli: Stereospecific recognition of ferric rhodotorulic acid (1)Biochemical and Biophysical Research Communications, 1984
- The Significance of Iron in InfectionClinical Infectious Diseases, 1981
- A Bactericidal Effect for Human LactoferrinScience, 1977
- Enterochelin hydrolysis and iron metabolism in Escherichia coliBiochimica et Biophysica Acta (BBA) - General Subjects, 1971