REVERSAL OF d -CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE

Abstract

Reversal of the antibacterial activity of D-4-amino-3-isoxazolidone by alanine in bacterial cultures actively growing on chemically defined media was compared in cultures requiring exogenous alanine and those capable of its synthesis. DL-Alanine was the most effective reversal agent in Pediococcus cerevisiae. an alanine-requiring organism, and D-ala-nine was effective in Escherichia coli and Staphylococcus aureus, organisms synthesizing alanine. With all three cultures, L-alanine was the least effective reversal agent.